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예성수 교수
E-mail : ssyea@inje.ac.kr

연구분야

- 면역세포 신호전달 연구
- PI3K/mTOR신호전달 기전
- 면역기능조절,항암면역,항산화면역 연구
- 화합물의 약리/독성 평가 및 분자세포생물학적 작용기전 규명
학력사항

- 연세대학교 이과대학 생화학과 학사 (1994)
- 한국과학기술원(KAIST) 생물과학과 석사 (1996)
- 한국과학기술원(KAIST) 생물과학과 박사 (2000)
경력사항

- Michigan State University, Visiting Scholar (1997~1998)
- 인제대학교 백인제기념연구소 연구강사(2000~2001)
- 인제대학교 의과대학 생화학교실 전임강사 (2001~2003)
- 인제대학교 의과대학 생화학교실 조교수 (2003~2007)
- 환경부 내분비계장애물질 전문위원 (2005~2007)
- 대한독성유전?단백체학회 상임이사 (2005~2010)
- Molecular & Cellular Toxicology 편집위원 (2006~2010)
- 인제대학교 의과대학 생화학교실 부교수 (2007~2013)
- University of California, Irvine, Visiting Associate Researcher (2011~2013)
- 인제대학교 의과대학 생화학교실 교수 (2013~현재)
- Journal of Life Science, 편집위원 (2013~현재)
- 한국실험혈액학연구회 감사 (2014~현재)
- 인제대학교 의과대학 생화학교실 주임교수 (2016~현재)
- 식품의약품안전평가원 KNTP 독성시험평가 전문위원 (2017~현재)
- 한국생명과학회 평의원 (~현재)
- 생화학분자생물학회 종신회원(~현재)
- 한국독성학회/한국환경성돌연변이발암원학회 임원 (~현재)
주요 연구물

- Choi JH, Kim KH, Roh KH, Jung H, Lee AB, Lee JY, Song JY, Park SJ, Kim I, Lee WS, Seo SK, Choi IW, Fu YX, Yea SS*, Park S*. 2018.A PI3K p110α-selective inhibitor enhances the efficacy of anti-HER2/neu antibody therapy against breast cancer in mice. Oncoimmunol.

- Park H, Lee DS, Yim MJ, Choi YH, Park SG, Seo SK, Choi JS, Jang WH, Yea SS, Park WS, Lee CM, Jung WK, Choi IW. 2015. 3,3'-Diindolylmethane inhibits VEGF expression through the HIF-1aand NF-kB pathways in human retinal pigment epithelial cells under chemical hypoxic conditions. Int. J. Mol. Med. 36:301-308.

- Yea SS, So S, Mallya S, Lee J, Rajasekaran K,Malarkannan S, Fruman DA. 2014. Effects of novel isoform-selectivephosphoinositide 3-kinase inhibitorson natural killer cell function. PLOS-ONE 9(6):e99486 (1-13).

- Yang JW, Jung WK, Lee CM, Yea SS, Choi YH, Kim GY, Lee DS, Na G, Park SG, Seo SK, Choi JS, Lee CM, Park WS, Choi IW. 2014. Caffeic acid phenethyl ester inhibits the inflammatory effects of interleukin-1β in human corneal fibroblasts. Immunopharmacol. Immunotoxicol. 36(5):371-377.

- Lee CM, Jung WK, Na G, Lee DS, Park SG, Seo SK, Yang JW, Yea SS, Lee MY, Park WS, Choi IW. 2015. Inhibitory effects of the platelet-activating factor receptor antagonists, CV-3988 and Ginkgolide B, on alkali burn-induced corneal neovascularization. Cutan. Ocul. Toxicol. 34(1):53-60.

- Yea SS, Fruman DA. 2013. Achieving cancer cell death with PI3K/mTOR-targeted therapies. Ann. NY Acad. Sci. 1280(1):15-18.

- So L, Yea SS, Oak JS, Lu M, Manmadhan A, Ke QH,Janes MR, Kessler LV, Kucharski JM, Li LS, Martin MB, Ren P, Jessen KA, Liu Y, Rommel C. Fruman DA. 2013. Selective inhibition of phosphoinositide 3-kinase p110apreserves lymphocyte function. J. Biol. Chem. 288(8):5718-5731.

- Wu Z, Lee D, Joo J, Shin JH, Kang W, Oh S, Lee DY, Lee SJ, Yea SS, Lee HS, Lee T, Liu KH. 2013. CYP2J2 and CYP2C19 are the Major Enzymes Responsible for Metabolism of Albendazole and Fenbendazole in Human Liver Microsomes and Recombinant P450 Assay Systems. Antimicrob. AgentsChemother.57(11):5448-5456.

- Kong CS, Lee JI, Kim YA, Kim JA, Bak SS, Hong JW,Park HY, Yea SS, Seo YW. 2012. Evaluation on anti-adipogenic activity of flavonoid glucopyranosides fromSalicornia herbacea. Process Biochem. 47(7):1073?1078.

- Yea SS, Fruman DA. 2011. New mTOR Targets Grb Attention. Science 332:1270-1271.

- Park WS, Jung WK, Park SK, Heo KW, Kang MS,Choi YH, Kim GY, Park SG, Seo SK, Yea SS, Liu KH,Shim EB, Kim DJ, Her M, Choi IW. 2011. Expression of galectin-9 by IFN-γ stimulated human nasal polyp fibroblasts through MAPK, PI3K, and JAK/STAT signaling pathways.Biochem.Biophys. Res.Commun.411(2):259-64.

- Park WS, Jung WK,Lee DY, Moon C,Yea SS,Park SG,Seo SK,Park C,Choi YH, Kim GY, Choi JS, Choi IW. 2010. Cilostazol protects mice against endotoxin shock and attenuates LPS-induced cytokine expression in RAW 264.7 macrophages via MAPK inhibition and NF-kB inactivation: Not involved in cAMP mechanisms.Int. Immunopharmacol. 10:1077-1085.

- Kong CS, Um YR, Lee JI, Kim YA, Yea SS, Seo YW. 2010. Constituents isolated from Glehnialittoralis suppress proliferations of humancancer cells and MMP expression in HT1080 cells. Food Chem. 120(2):385-394.

- Kim YA, Kong CS, Yea SS, Seo YW. 2010. Constituents of Corydalis heterocarpa and their anti-proliferative effects on human cancer cells. Food Chem. Toxicol. 48(2):722-728.

- Jung WK,Lee DY,Park C,Choi YH, Choi IH,Park SG,Seo SK,Lee SW,Yea SS,Ahn SC, Lee CM,Park WS, Ko JH,Choi IW. 2010. Cilostazol is anti-inflammatory in BV2 microglial cells by inactivating nuclear factor-kappaB and mitogen-activated protein kinases.Br. J.Pharmacol. 159(6):1274-1285.

- Li MH, Kothandan G, Cho SJ, Huong PT, Nan YH, Lee KY, Shin SY, Yea SS, Jeon YJ. 2010. Magnolol Inhibits LPS-induced NF-kB/Rel Activation by Blocking p38 Kinase in Murine Macrophages. Korean J. Physiol. Pharmacol. 14(6):353-358.

- Um YR, LeeJI, Lee JH, Kim HJ, Yea SS, Seo YW. 2010. Chemical Constituents of the Halophyte Glehnialittoralis. J. Kor. Chem. Soc. 54(6):701-706.

- Kumar KS, Choo KS, Yea SS, Seo YW, Han TJ. 2010. Effects of the PhenylureaHerbicide Diuron on the Physiology of Saccharina japonica. Aresch. ToxEHS 2(3):188-199.

- Kim YA, Lee JI, Kong CS, Yea SS, Seo YW. 2009. Antiproliferative Effect of Extracts from Corydalis heterocarpa on Human Cancer Cells. KSBB J. 24(2):201-206.

- Lee JI, Kim YA, Kong CS, Yea SS, Han TJ, Kang SH, Kim JH, Seo YW. 2009. Antioxidant Activity of Seaweed Extracts from Kongsfjorden, an Inlet in the Arctic’s Svalbard Archipelago. Ocean and Polar Research 31(2):213-218.

- Jung WK,Ahn YW, Lee SH, Choi YH, Kim SK, Yea SS, Choi IH, Park SG, Seo SK, Lee SW, Choi IW. 2009. Ecklonia cavaethanolic extracts inhibit lipopolysaccharide-induced cyclooxygenase-2 andinducible nitric oxide synthase expression in BV2 microglia via the MAP kinase and NF-kB pathways. Food Chem. Toxicol. 47(2):410-417.

- Jung WK, Park IS, Park SJ, Yea SS, Choi YH, Oh S,Park SG, Choi IW. 2009. The 15-Deoxy-Δ12,14-prostaglandin J2 inhibits LPS-stimulated AKT and NF-κBactivation and suppresses interleukin-6 in osteoblast-like cells MC3T3E-1. Life Sci. 85:46?53.

- Choi CY, Jo GH, Lee JH, Seo YW, Han TJ, Choi IW, Liu KH, Oh S, Kim DE, Jang WH, Seog DH, Park YH, Yea SS. 2009. AlariaesculentaExtract Protects against Oxidative Damage by Inducing HemeOxygenase-1 Expression via Akt and Nrf2. Mol. Cell. Toxicol. 5(2):120-125.

- Kim YA, Kong CS, Um YR, Lim SY, Yea SS, Seo YW. 2009. Evaluation of Salicornia herbacea as a potential antioxidant and anti-inflammatory agent. J. Med. Food. 12(3):661-668.

- Lee B, Park SY, Heo YS, Yea SS, Kim DE. 2009. Efficient Colorimetric Assay of RNA Polymerase ActivityUsing Inorganic Pyrophosphatase and Ammonium Molybdate. Bull. Kor. Chem. Soc. 30(10):2485-2488.

- Park SG, Lee DY, Seo SK, Lee SW, Kim SK, Jung WK,Kang MS, Choi YH, Yea SS, Choi IH, Choi IW. 2008. Evaluation of anti-allergic properties of caffeic acid phenethyl ester in a murine model of systemic anaphylaxis. Toxicol. Appl. Pharmacol.226(1):22-29.

- Cho M, Park S,Gwak J, Kim DE, Yea SS, Shin JG, Oh S. 2008. Bisindoylmaleimide I suppresses adipocyte differentiation through stabilization of intracellular β-catenin protein. Biochem. Biophys. Res. Commun. 367:195-200.

- Yea SS, Lee SS, Kim WY, Liu KH, Kim H, Shon JH, Cha IJ, Shin JG. 2008. Genetic variations and haplotypes of UDP-glucuronosyltransferase 1Alocus in a Korean population. Ther. Drug Monit. 30(1):23-34.

- Jung WK, Lee DY, Choi YH, Yea SS, Choi IH, Park SG, Seo SK, Lee SW, Lee CM, Kim SK, Jeon YJ, Choi IW. 2008. Caffeic acid phenethyl ester attenuates allergic airway inflammation and hyperresponsiveness in murine model of ovalbumin-induced asthma. Life Sci. 82:797-805.

- Kim SK, Lee DY, Jung WK, Kim JH, Choi IH, Park SG, Seo SK, Lee SW, Lee CM, Yea SS, Choi YH, Choi IW.2008. Effects of Ecklonia cavaethanolic extracts on airwayhyperresponsiveness and inflammation in a murine asthma model: Role of suppressor of cytokine signaling. Biomed.Pharmacother.62:289-296

- Kim H, Kim KB, Ku HY, Park SJ, Choi H, Moon JK, Park BS, Kim JH, Yea SS, Lee CH, Lee HS, Shin JG, Liu KH. 2008. Identification and characterization of potent CYP2B6 inhibitors in Woohwangcheongsimwon suspension, an herbal preparation used in the treatment and prevention of apoplexy in Korea and China. Drug Metab. Dispos. 36:1010-1015

- Jung WK, Choi IH, Lee DY, Yea SS, Choi YH,Kim MM, Park SG, Seo SK, Lee SW, Lee CM,Park YM, Choi IW. 2008. Caffeic acid phenethyl ester protects mice from lethal endotoxin shockand inhibits lipopolysaccharide-induced cyclooxygenase-2 andinducible nitric oxide synthase expression in RAW264.7macrophages via the p38/ERK and NF-kB pathways. Int. J. Biochem. Cell Biol. 40:2572-2582.

- Jang WH, Yang YI, Lee YJ, Chun JH, Yea SS, Seog DH, Kim HI. 2008. Lack of association between tumor necrosis factor-a -308 and -238 promoter polymorphisms and chronic hepatitis B virus infection. J. Life Sci. 18(9):1207-1211.

- Park KR, Lee JH, Choi CY, Liu KH, Seog DH, Kim YH, Kim DE, Yun CH, Yea SS. 2007. Suppression of interleukin-2 gene expression by isoeugenol is mediated through down-regulation of the NF-AT and NF-kB. Int. Immunopharmacol. 7: 1251-1258.

- Choi CY, Park KR, Lee JH, Jeon YJ, Liu KH, Oh S, Kim DE, Yea SS. 2007. Isoeugenol suppression of inducible nitric oxide synthase expression is mediated by down-regulation of NF-kB, ERK1/2, and p38 kinase. Eur. J. Pharmacol.576:151-159.

- Shin JG, Yea SS, Lee SS, Kim WY, Cha IJ. Single nucleotide polymorphic of UDP-glucuronosyltrasferase 1A4 and use thereof. 2008 Korea Patent (10-0849166)

- Yea SS, Choi CY, Seo YW, Choi IW, Han TJ. Composition for antioxidation and preventing or treating immune disease comprising Alariaesculenta extract as an active ingredient. 2010 Korea Patent (10-0972167)

- Shin JG, Kim WY, Yea SS, Lee SS, Kim EY. Method for determining polymorphisms and functional mutations of UDP-glucuronosyltransferase 1A genes. 2011 Korea Patent (10-1057128)

- Seo YW, Nam TJ, Kim YA, Kong CS, Lee JL, Yea SS, Han TJ. Compositions for preventing obesity. 2011 Korea Patent (10-1072904)

- Yea SS, Jo GH, Seo YW, Han TJ, Choi IH. Composition for preventing and treating of cancer containing Chorda filum extract as active ingredient. 2011 Korea Patent (10-1078091)

- Yea SS, Choi CY, Choi IH, Song YS. Composition for preventing or treating immune disease comprising dandelion water extract as an active ingredient. 2013 Korea Patent (10-1307501)

- Yea SS. Composition for preventing or treating cancer comprising the extract of Sargassumthunbergii. 2017 Korea Patent (10-1794114)

- Yea SS, Kim MR, Ock YA. Composition for preventing or treating oxidative disease comprising the selective PI3K p110δ inhibitor. 2018 Korea Patent (10-1818364)