 장지은 교수 E-mail : JIEUN120@yuhs.ac |
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연구분야 급성백혈병 혈액암의 약제내성 기전 백혈병줄기세포 면역세포치료 |
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학력사항 연세대학교 의과대학 졸업 (2007년) 연세대학교 의학과 대학원 박사 (2019년) |
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경력사항 2007~2008 세브란스 병원 인턴 2008~2012 세브란스 병원 내과 전공의 2013~2016 연세대학교 의과대학 내과학교실 강사 2016~2017 연세대학교 의과대학 내과학교실 임상조교수 2017~2021 연세대학교 의과대학 내과학교실 조교수 2023~2025 Harvard Medical School/ Dana Faber Cancer Institute 방문교수 2022~현재 연세대학교 의과대학 내과학교실 부교수 |
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주요 연구물 1. Risk factors for progression from cytomegalovirus viremia to cytomegalovirus disease after allogeneic hematopoietic stem cell transplantation / Biology of Blood and Marrow Transplantation /2012 Jun;18(6):881-6 2. Early CMV replication and subsequent chronic GVHD have a significant anti-leukemic effect after allogeneic HSCT in acute myeloid leukemia /Annals of Hematology/2015 Feb; 94:275–282 3. Single monosomy as a relatively better survival factor in acute myeloid leukemia patients with monosomal karyotype / Blood Cancer Journal / 2015 Oct; 5, e358 4. A new prognostic model using absolute lymphocyte count in patients with primary central nervous system lymphoma / European Journal Of Cancer / 2016 Apr; 57:127-135 5. Selection of a mobilization regimen for multiple myeloma based on the response to induction therapy:Granulocyte-colony stimulating factor (G-CSF) alone versus high-dose cyclophosphamide plus G-CSF / Leukemia and lymphoma / 2016 Jun;57(6):1389-97 6. Targeting AMPK-ULK1-mediated autophagy for combating BET inhibitor resistance in acute myeloid leukemia stem cells / AUTOPHAGY /2017 Apr;13(4):761-762 7. AMPK-ULK1-mediated autophagy confers resistance to BET inhibitor JQ1 in acute myeloid leukemia stem cells / Clinical Cancer Research /2017 Jun;23(11):2781-2794 8. Early Cytomegalovirus Reactivation and Expansion of CD56brightCD16dim/DNAM1+ Natural Killer Cells Are Associated with Antileukemia Effect after Haploidentical Stem Cell Transplantation in Acute Leukemia / Biology of Blood and Marrow Transplantation /2019 Oct;25:2070-2078 9. PERK/NRF2 and autophagy form a resistance mechanism against G9a inhibition in leukemia stem cells / Journal of Experimental & Clinical Cancer Research / 2020 Apr; 39:e66 10. Arsenic trioxide synergistically promotes the antileukaemic activity of venetoclax by downregulating Mcl-1 in acute myeloid leukaemia cells / Experimental Hematology and Oncology /2021 Apr;10:28 11. Development of a Next-Generation Sequencing-Based Gene Panel Test to Detect Measurable Residual Disease in Acute Myeloid Leukemia / Annals of Laboratory Medicine / 2023 12. DRP1 Inhibition Enhances Venetoclax-Induced Mitochondrial Apoptosis in TP53-Mutated Acute Myeloid Leukemia Cells through BAX/BAK Activation / Cancers / 2023, 15, 745 |
