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조석구 교수
E-mail : chosg@catholic.ac.kr

연구분야

I. 임상연구
암 > 혈액학 > 림프종 & 만성 림프구성 백혈병
자가 & 동종 조혈모세포이식
암 > 종양면역치료

II. 기초연구
종양면역치료제 개발 > EBV 관련 림프종에 대한 EBV-CTL 치료 연구
자가 & 동종 조혈모세포이식 후 입양세포치료법 연구
고형장기이식 후 의도적 혼합키메라 유도 연구
성체 중간엽줄기세포와 면역조절세포를 이용한 병용세포치료 기반 면역조절 연구
분자영상을 이용한 중개의학 연구
학력사항

가톨릭대학교 의학과 졸업 (1988)
가톨릭대학교 대학원 내과학 석사 (1992)
가톨릭대학교 대학원 내과학 박사 (1998)
경력사항

가톨릭대학교 강남성모병원 수련의 (1988-1989)
가톨릭대학교 강남성모병원 내과 전문의 (1989-1992)
가톨릭대학교 강남성모병원 혈액종양내과 임상강사 (1995-1996)
가톨릭대학교 강남성모병원 혈액종양내과 전임강사 (1997-1999)
가톨릭대학교 강남성모병원 혈액종양내과 조교수 (1999-2003)
The University of Tokyo (IMUST), Department of Molecular therapy, The Institute of Medical Science, A scholarship research fellow of a TBRF (Tokyo Biochemical Research Foundation) postdoctoral fellowship program (2001-2003)
가톨릭대학교 여의도성모병원 혈액종양내과 부교수 (2003-2009)
가톨릭대학교 서울성모병원 혈액종양내과 교수 (2009-현재)
가톨릭대학교 서울성모병원 세포치료센터 센터장 (2009-현재)
가톨릭대학교 세포치료사업단 단장 (2013-현재)
가톨릭대학교 중개의학분자영상연구소 소장 (2014-현재)
한국실험혈액학회 회장 (2015-현재)
주요 연구물

1. Kim N, Nam YS, Im KI, Lim JY, Jeon YW, Song Y, Lee JW, Cho SG. Robust production of CMV pp65-specific T cells by a fully automated IFN-γ cytokine capture system. Transfusion Medicine and Hemotherapy. In press.

2. Kim N, Cho SG. Alternative approaches to preserve MSC progenitor potency. Blood Res. 2017 Mar;52(1):1-2. doi: 10.5045/br.2017.52.1.1. Epub 2017 Mar 27.

3. Lim JY, Im KI, Lee ES, Kim N, Nam YS, Jeon YW, Cho SG: Enhanced immunoregulation of mesenchymal stem cells by il-10-producing type 1 regulatory t cells in collagen-induced arthritis. Scientific reports 2016;6:26851.

4. Kim N, Jeon YW, Nam YS, Lim JY, Im KI, Lee ES, Cho SG: Therapeutic potential of low-dose il-2 in a chronic gvhd patient by in vivo expansion of regulatory t cells. Cytokine 2016;78:22-26.

5. Kim N, Cho SG: Overcoming immunoregulatory plasticity of mesenchymal stem cells for accelerated clinical applications. International journal of hematology 2016;103:129-137.

6. Nam YS, Kim N, Im KI, Lim JY, Lee ES, Cho SG: Negative impact of bone-marrow-derived mesenchymal stem cells on dextran sulfate sodium-induced colitis. World journal of gastroenterology 2015;21:2030-2039.

7. Lim JY, Park MJ, Im KI, Kim N, Park HS, Lee SH, Kim EK, Nam YS, Lee ES, Cho ML, Cho SG: Interleukin 21 blockade modulates activated t- and b-cell homeostasis via b-cell activating factor pathway-mediated inhibition in a murine model of acute graft-versus-host disease. Experimental hematology 2015;43:23-31 e21-22.

8. Lee ES, Lim JY, Im KI, Kim N, Nam YS, Jeon YW, Cho SG: Adoptive transfer of treg cells combined with mesenchymal stem cells facilitates repopulation of endogenous treg cells in a murine acute gvhd model. PloS one 2015;10:e0138846.

9. Kim N, Nam YS, Im KI, Lim JY, Lee ES, Jeon YW, Cho SG: Il-21-expressing mesenchymal stem cells prevent lethal b-cell lymphoma through efficient delivery of il-21, which redirects the immune system to target the tumor. Stem cells and development 2015;24:2808-2821.

10. Kim N, Lee H, Shin J, Nam YS, Im KI, Lim JY, Lee ES, Kang YN, Park SH, Cho SG: Immune reconstitution kinetics following intentionally induced mixed chimerism by nonmyeloablative transplantation. PloS one 2015;10:e0126318.

11. Kim N, Cho SG: New strategies for overcoming limitations of mesenchymal stem cell-based immune modulation. International journal of stem cells 2015;8:54-68.

12. Kim M, Yahng SA, Kwon A, Park J, Jeon YW, Yoon JH, Shin SH, Lee SE, Cho BS, Eom KS, Lee S,

13. Im KI, Kim N, Lim JY, Nam YS, Lee ES, Kim EJ, Kim HJ, Kim SH, Cho SG: The free radical scavenger necrox-7 attenuates acute graft-versus-host disease via reciprocal regulation of th1/regulatory t cells and inhibition of hmgb1 release. Journal of immunology 2015;194:5223-5232.

14. Cho SG, Kim N, Sohn HJ, Lee SK, Oh ST, Lee HJ, Cho HI, Yim HW, Jung SE, Park G, Oh JH, Choi BO, Kim SW, Chung NG, Lee JW, Hong YS, Kim TG: Long-term outcome of extranodal nk/t cell lymphoma patients treated with postremission therapy using ebv lmp1 and lmp2a-specific ctls. Molecular therapy : the journal of the American Society of Gene Therapy 2015;23:1401-1409.

15. Lim JY, Park MJ, Im KI, Kim N, Jeon EJ, Kim EJ, Cho ML, Cho SG: Combination cell therapy using mesenchymal stem cells and regulatory t-cells provides a synergistic immunomodulatory effect associated with reciprocal regulation of th1/th2 and th17/treg cells in a murine acute graft-versus-host disease model. Cell transplantation 2014;23:703-714.

16. Im KI, Park MJ, Kim N, Lim JY, Park HS, Lee SH, Nam YS, Lee ES, Lee JH, Cho ML, Cho SG: Induction of mixed chimerism using combinatory cell-based immune modulation with mesenchymal stem cells and regulatory t cells for solid-organ transplant tolerance. Stem cells and development 2014;23:2364-2376.

17. Lee JH, Jeon EJ, Kim N, Nam YS, Im KI, Lim JY, Kim EJ, Cho ML, Han KT, Cho SG: The synergistic immunoregulatory effects of culture-expanded mesenchymal stromal cells and cd4(+)25(+)foxp3+ regulatory t cells on skin allograft rejection. PloS one 2013;8:e70968.

18. Kim N, Im KI, Lim JY, Jeon EJ, Nam YS, Kim EJ, Cho SG: Mesenchymal stem cells for the treatment and prevention of graft-versus-host disease: Experiments and practice. Annals of hematology 2013;92:1295-1308.

19. Jeon EJ, Yoon BY, Lim JY, Oh HJ, Park HS, Park MJ, Lim MA, Park MK, Kim KW, Cho ML, Cho SG: Adoptive transfer of all-trans-retinal-induced regulatory t cells ameliorates experimental autoimmune arthritis in an interferon-gamma knockout model. Autoimmunity 2012;45:460-469.

20. Park MJ, Park HS, Cho ML, Oh HJ, Cho YG, Min SY, Chung BH, Lee JW, Kim HY, Cho SG: Transforming growth factor beta-transduced mesenchymal stem cells ameliorate experimental autoimmune arthritis through reciprocal regulation of treg/th17 cells and osteoclastogenesis. Arthritis and rheumatism 2011;63:1668-1680.